top of page
- Little is known regarding the
natural progression of many animal diseases or the true efficacy of the treatments provided
these animals. Databases such as the ones developed by CARE will be critical in improving
health care of veterinary patients by providing a reliable, sophisticated resource for
investigators to review or collect information on these patients (prospective and
retrospectives studies as well as clinical trials).
- Animal & human diseases are often similar in their cause & natural
progression & because environmental factors affecting domestic animals and their owners
are typically the same, animals with spontaneous disease represent an excellent model for
- Studying spontaneous disease has numerous benefits in terms of relevance and cost
over creating experimental models of animals.
- The promotion of evidence-based medicine requires a systematic method of capturing
information regarding naturally occurring animal disease and its response to environmental
factors (including diet) and therapy.
- Experimental models using laboratory animals (even genetically engineered lab
animals) are not good predictors of human efficacy
- Our dependence on experimental animals as our only preclinical index of potential
- Wastes animal lives and money
- Lengthens the “critical pathway” for drug development, since drugs may work in an
experimental model, but fail once they are in human clinical trials
- Increases the cost of human healthcare
- Provides a major barrier to development of drugs for orphan diseases or for veterinary use where markets are
not large enough to warrant the cost of development
- Using animals with spontaneous disease for clinical studies has the potential to
reduce the cost of healthcare and change the “critical pathway” for drug,
device, and product development worldwide
1. Improving our understanding of disease
- Ability to study the pathogenesis of disease & its effect on animals in natural
- Ability to apply evidence-based medicine to veterinary practice.
- Reduction in the number of companion animals needed for research.
- Identification of new, relevant models of spontaneous diseases for drug development
and device testing.
- Investigation & identification of appropriate genomic studies in animal
populations that will further our knowledge and understanding of the etiology and heredity
of diseases affecting animals and humans.
- Education of industry and health professionals in various disciplines regarding the
importance of studying spontaneous disease in animals and the vital, unique contribution
such information will make on human and animal health.
2. Benefits to Pets & Owners
top of page
- Development of new drugs, devices and diagnostic procedures with direct application
to the health of pets and their owners.
- Reduced cost of veterinary care to owners whose pets are enrolled in clinical
- Availability of leading edge veterinary care for animal patients who are enrolled
in clinical studies.
1. Developing a Knowledge Base
- Identification of spontaneous animal diseases relevant to human diseases.
- Development of a registry for animals with spontaneous diseases (RESPOND™), a
structured database providing a unique source of information on naturally occurring
(spontaneous) animal disease.
- Identification and registration of animals with relevant spontaneous disease whose
owners are interested in participating in clinical studies.
2. Developing the Framework & Competence
top of page
- Establishing a regional network of veterinarians capable of conducting clinical
- Establishing an organization to monitor clinical animal studies and ensure the
greatest opportunity for success of these endeavors.
- Interfacing with and educating human and veterinary industry personnel, physicians,
veterinarians, and researchers of the benefits of utilizing animals with spontaneous disease.